Our review of PerioBrite all natural toothpaste… Is PerioBrite really Nature’s Answer? Let’s find out. Well, the company is U.S.A. based and family owned located in Hauppauge, New York. Their facility houses a pharmaceutically licensed, Kosher-inspected, NSF certified, Organic Certified manufacturing operation, R&D Lab, QC Dept., Microbiological Lab and Modern Warehousing Complex. PerioBrite has been on the market since 1972. When it comes to ingredients PerioBrite definitely leads the pack having one of the most clean ingredients list on the market. PerioBrite toothpaste ingredients include: Calcium carbonate, glycerin, water, sodium bicarbonate, cellulose gum, Bio-Saponins® (yucca schidigera root extract, quillaja saponaria root extract, dioscorea villosa (wild yam) tuber extract, smilax regelii root extract), mentha piperita (peppermint) oil, xylitol, lysine, xanthan, calendula…